In a small bowl, combine cream cheese, Cheddar, 1/8 teaspoon garlic powder, and 1/8 teaspoon onion powder. Mix thoroughly.
In a wide bowl, combine bread crumbs, salt, black pepper, remaining 1/8 teaspoon garlic powder, and remaining 1/8 teaspoon onion powder. Mix well.
Place egg whites or egg substitute in a second wide bowl.
Halve jalapeño peppers lengthwise, and remove seeds and stems. Spread the cheese mixture into the pepper halves.
Coat the pepper halves with the egg, followed by the seasoned bread crumbs.
Spray an air fryer with nonstick spray. Place pepper halves in the air fryer, and spray with nonstick spray.
Set air fryer to 390ºF (200°C). Cook until golden brown and tender, about 8 minutes. Remove from the air fryer. Garnish with fresh parsley, if desired, and serve immediately.