Toss the ice, tequila, lime juice, orange liqueur, and Simple Syrup in a blender and blitz on high speed until smooth.
Make the lime, salt, and sugar rim
Combine the lime zest, salt, and sugar in a small blender or mini food processor and blend until thoroughly combined and very finely chopped. You should have about 1/4 cup. Dump about 1 tablespoon of the lime, salt, and sugar mixture onto a plate. Run a lime wedge around the rims of 2 chilled glasses—they can be margarita glasses, wineglasses, rocks glasses, pint glasses, whatever—and press the rims into the mixture to coat the edge.
Assemble the margarita
Pour the margarita into the glasses and garnish with the lime wedges.