In a pot over medium-high heat, combine the heavy cream, milk, and sugar and bring to a simmer, stirring constantly to prevent scorching. Remove the pot from the heat.
In a heatproof bowl, whisk the egg yolks until smooth. Very slowly drizzle 1/3 of the hot milk mixture into the egg yolks, whisking constantly. Pour the egg yolk mixture into the saucepan, whisking constantly. Add the vanilla bean and seeds to the mixture and whisk until combined.
Return the pot to low heat and stir the custard with a wooden spoon until the mixture thickens slightly and coats the back of the spoon, 7 to 8 minutes.
Immediately remove the custard from the heat and stir in the bourbon. Strain the mixture through a fine-mesh strainer into a bowl and cover with plastic wrap, gently pressing the plastic against the surface of the custard. Refrigerate for at least 2 hours and preferably overnight.
Transfer the chilled custard to an ice cream maker and process according to manufacturer’s instructions. Remove the ice cream from the machine, transfer to a resealable container, and freeze for at least 2 hours or until firm.